New approaches for solving the old problem

Infantile hemangioma (IH) is a benign vascular tumor with abnormal proliferation of endothelial cells and impaired architecture. It believed that the pathogenesis IH based on angiogenesis impairment caused by imbalance between angiogenic anti-angiogenic factors. Despite spontaneous regression, which observed in 90% cases IH, several localizations may indicate possibility systemic manifestations or lead to development complications require medical interventions. Here we report 2 most frequent severe first successful use combined treatment strategy including metronomic chemotherapy (cyclophosphamide plus vinblastine) nonselective b-blocker (propranolol) IH. The parents patients agreed information, photographs children, scientific research publications. In contrast glucocorticoids commonly used clinical practice for complicated forms showed high efficacy safety. led rapid, within two weeks, improvement resulting not only stopping growth, but even size reduction. Such rapid response therapy allowed stop ulcers necrosis secondary infection, prevent vital such as upper respiratory tract compression.